Differential responsiveness of innate-like IL-17- and IFN-gamma-producing gammadelta T cells to homeostatic cytokines
- Author(s)
- Corpuz, TM; Stolp, J; Kim, HO; Pinget, GV; Gray, DH; Cho, JH; Sprent, J; Webster, KE;
- Details
- Publication Year 2016-01-15,Volume 196,Issue #2,Page 645-54
- Journal Title
- Journal of Immunology
- Publication Type
- Journal Article
- Abstract
- gammadelta T cells respond to molecules upregulated following infection or cellular stress using both TCR and non-TCR molecules. The importance of innate signals versus TCR ligation varies greatly. Both innate-like IL-17-producing gammadelta T (gammadeltaT-17) and IFN-gamma-producing gammadelta T (gammadeltaT-IFNgamma) subsets tune the sensitivity of their TCR following thymic development, allowing robust responses to inflammatory cytokines in the periphery. The remaining conventional gammadelta T cells retain high TCR responsiveness. We determined homeostatic mechanisms that govern these various subsets in the peripheral lymphoid tissues. We found that, although innate-like gammadeltaT-17 and gammadeltaT-IFNgamma cells share elements of thymic development, they diverge when it comes to homeostasis. Both exhibit acute sensitivity to cytokines compared with conventional gammadelta T cells, but they do not monopolize the same cytokine. gammadeltaT-17 cells rely exclusively on IL-7 for turnover and survival, aligning them with NKT17 cells; IL-7 ligation triggers proliferation, as well as promotes survival, upregulating Bcl-2 and Bcl-xL. gammadeltaT-IFNgamma cells instead depend heavily on IL-15. They display traits analogous to memory CD8(+) T cells and upregulate Bcl-xL and Mcl-1 upon cytokine stimulation. The conventional gammadelta T cells display low sensitivity to cytokine-alone stimulation and favor IL-7 for their turnover, characteristics reminiscent of naive alphabeta T cells, suggesting that they may also require tonic TCR signaling for population maintenance. These survival constraints suggest that gammadelta T cell subsets do not directly compete with each other for cytokines, but instead fall into resource niches with other functionally similar lymphocytes.
- Publisher
- ASI
- Research Division(s)
- Molecular Genetics Of Cancer
- PubMed ID
- 26673141
- Publisher's Version
- https://doi.org/10.4049/jimmunol.1502082
- NHMRC Grants
- NHMRC/1049724,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2016-01-13 02:34:06
Last Modified: 2016-01-13 02:48:52