Total synthesis of a biotinylated rocaglate: Selective targeting of the translation factors eIF4AI/II
Publication Year 2016-01-15, Volume 26, Issue #2, Page 262-4
Journal Title
Bioorg Med Chem Lett
Publication Type
Journal Article
The total synthesis of a biotinylated derivative of methyl rocaglate is described. This compound was accessed from synthetic methyl rocaglate (2) via formation of the propargyl amide and subsequent click reaction with a biotin azide. Affinity purification revealed that biotinylated rocaglate (8) and methyl rocaglate (2) bind with high specificity to translation factors eIF4AI/II. This remarkable selectivity is in line with that found for the more complex rocaglate silvestrol (3).
WEHI Research Division(s)
Cell Signalling And Cell Death
PubMed ID
NHMRC Grants
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Creation Date: 2016-01-13 02:34:05
Last Modified: 2016-01-13 02:40:15
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