Total synthesis of a biotinylated rocaglate: Selective targeting of the translation factors eIF4AI/II
Details
Publication Year 2016-01-15, Volume 26, Issue #2, Page 262-4
Journal Title
Bioorg Med Chem Lett
Publication Type
Journal Article
Abstract
The total synthesis of a biotinylated derivative of methyl rocaglate is described. This compound was accessed from synthetic methyl rocaglate (2) via formation of the propargyl amide and subsequent click reaction with a biotin azide. Affinity purification revealed that biotinylated rocaglate (8) and methyl rocaglate (2) bind with high specificity to translation factors eIF4AI/II. This remarkable selectivity is in line with that found for the more complex rocaglate silvestrol (3).
Publisher
Elsevier
WEHI Research Division(s)
Cell Signalling And Cell Death
PubMed ID
26718843
NHMRC Grants
NHMRC/1035502
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2016-01-13 02:34:05
Last Modified: 2016-01-13 02:40:15
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