Total synthesis of a biotinylated rocaglate: Selective targeting of the translation factors eIF4AI/II
- Author(s)
- Chambers, JM; Lindqvist, LM; Savage, GP; Rizzacasa, MA;
- Details
- Publication Year 2016-01-15,Volume 26,Issue #2,Page 262-4
- Journal Title
- Bioorg Med Chem Lett
- Publication Type
- Journal Article
- Abstract
- The total synthesis of a biotinylated derivative of methyl rocaglate is described. This compound was accessed from synthetic methyl rocaglate (2) via formation of the propargyl amide and subsequent click reaction with a biotin azide. Affinity purification revealed that biotinylated rocaglate (8) and methyl rocaglate (2) bind with high specificity to translation factors eIF4AI/II. This remarkable selectivity is in line with that found for the more complex rocaglate silvestrol (3).
- Publisher
- Elsevier
- Research Division(s)
- Cell Signalling And Cell Death
- PubMed ID
- 26718843
- Publisher's Version
- https://doi.org/10.1016/j.bmcl.2015.12.045
- NHMRC Grants
- NHMRC/1035502,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2016-01-13 02:34:05
Last Modified: 2016-01-13 02:40:15