Gastric band surgery leads to improved insulin secretion in overweight people with Type 2 diabetes

Wentworth, JM; Playfair, J; Laurie, C; Brown, WA; Burton, P; Shaw, JE; O&#39;Brien, PE

Author(s): Wentworth, JM; Playfair, J; Laurie, C; Brown, WA; Burton, P; Shaw, JE; O'Brien, PE;
Details: Publication Year 2015-12,Volume 25,Issue #12,Page 2400-7
Journal Title: Obes Surg
Publication Type: Journal Article
Abstract: BACKGROUND: We aimed to determine the effects of laparoscopic adjustable gastric band (LAGB) on beta-cell function in overweight people with type 2 diabetes and to assess the relationship between baseline beta-cell function and glycemic outcomes. METHODS: We studied 44 overweight but not obese people with type 2 diabetes who participated in a randomized trial whose primary outcome was the rate of diabetes remission after 2 years of multidisciplinary diabetes care (MDC group) or multidisciplinary care combined with LAGB. Dynamic beta-cell function was assessed by intravenous glucose challenge, and basal beta-cell function (HOMA-B) and insulin sensitivity (HOMA-S) were determined using the homeostatic model. RESULTS: Twelve LAGB participants and two MDC participants were in diabetes remission at 2 years. HOMA-S and the C-peptide response to intravenous glucose increased significantly in LAGB but not in MDC participants. The insulin response to glucose did not change in LAGB participants, whereas their fasting C-peptide/insulin ratio increased. Baseline measures of beta-cell function correlated with diabetes remission but not with reduction in HbA1c following LAGB. CONCLUSIONS: In overweight people with diabetes, LAGB improves endogenous beta-cell function after 2 years. Baseline beta-cell function correlated with diabetes remission, but not with HbA1c change following LAGB.
Publisher: Springer
Research Division(s): Population Health And Immunity
PubMed ID: 25994778
Publisher's Version: https://doi.org/10.1007/s11695-015-1716-5
Terms of Use/Rights Notice: Refer to copyright notice on published article.
Documents: Wentworth et al_Obesity Surgery_2015.pdf - (0.60MB, application/pdf)

Creation Date: 2016-01-12 10:21:46

Last Modified: 2019-04-01 08:58:07