T-box transcription factors combine with the cytokines TGF-beta and IL-15 to control tissue-resident memory T cell fate
Details
Publication Year 2015-12-15,Volume 43,Issue #6,Page 1101-11
Journal Title
Immunity
Publication Type
Journal Article
Abstract
Tissue-resident memory T (Trm) cells contribute to local immune protection in non-lymphoid tissues such as skin and mucosa, but little is known about their transcriptional regulation. Here we showed that CD8(+)CD103(+) Trm cells, independent of circulating memory T cells, were sufficient for protection against infection and described molecular elements that were crucial for their development in skin and lung. We demonstrated that the T-box transcription factors (TFs) Eomes and T-bet combined to control CD8(+)CD103(+) Trm cell formation, such that their coordinate downregulation was crucial for TGF-beta cytokine signaling. TGF-beta signaling, in turn, resulted in reciprocal T-box TF downregulation. However, whereas extinguishment of Eomes was necessary for CD8(+)CD103(+) Trm cell development, residual T-bet expression maintained cell surface interleukin-15 (IL-15) receptor beta-chain (CD122) expression and thus IL-15 responsiveness. These findings indicate that the T-box TFs control the two cytokines, TGF-beta and IL-15, which are pivotal for CD8(+)CD103(+) Trm cell development and survival.
Publisher
Cell Press
Research Division(s)
Molecular Immunology
PubMed ID
26682984
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2016-01-13 02:34:10
Last Modified: 2016-01-13 03:16:05
An error has occurred. This application may no longer respond until reloaded. Reload 🗙