Paracrine signaling between tumor subclones of mouse SCLC: a critical role of ETS transcription factor Pea3 in facilitating metastasis

Author(s): Kwon, MC; Proost, N; Song, JY; Sutherland, KD; Zevenhoven, J; Berns, A;
Details: Publication Year 2015-08-01,Volume 29,Issue #15,Page 1587-92
Journal Title: Genes Dev
Publication Type: Journal Article
Abstract: Tumor heterogeneity can create a unique symbiotic tumor microenvironment. Earlier, we showed that clonal evolution in mouse small cell lung cancer (SCLC) can result in subclones that, upon cografting, endow the neuroendocrine tumor cells with metastatic potential. We now show that paracrine signaling between SCLC subclones is a critical requirement in the early steps of the metastatic process, such as local invasion and intravasation. We further show evidence that paracrine signaling via fibroblast growth factor 2 (Fgf2) and Mapk between these diverged tumor subclones causes enhanced expression of the Pea3 (polyomavirus enhancer activator 3) transcription factor, resulting in metastatic dissemination of the neuroendocrine tumor subclones. Our data reveal for the first time paracrine signaling between tumor cell subclones in SCLC that results in metastatic spread of SCLC.
Publisher: CSHLP
Research Division(s): Stem Cells And Cancer
PubMed ID: 26215568
Publisher's Version: https://doi.org/10.1101/gad.262998.115
Open Access at Publisher's Site: http://genesdev.cshlp.org/content/29/15/1587.full
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2016-01-25 09:11:53

Last Modified: 2016-01-25 09:14:45