The NF-kappaB transcription factor RelA is required for the tolerogenic function of Foxp3 regulatory T cells
- Author(s)
- Messina, N; Fulford, T; O'Reilly, L; Loh, WX; Motyer, JM; ELLIS, D; McLean, C; Naeem, H; Lin, A; Gugasyan, R; Slattery, RM; Grumont, RJ; Gerondakis, S;
- Journal Title
- J Autoimmun
- Publication Type
- Journal Article in press
- Abstract
- The properties of CD4+ regulatory T cell (Treg) subsets are dictated by distinct patterns of gene expression determined by FOXP3 and different combinations of various transcription factors. Here we show the NF-kappaB transcription factor RelA is constitutively active in naive and effector Tregs. The conditional inactivation of Rela in murine FOXP3+ cells induces a rapid onset, multi-focal autoimmune disease that depends on RelA being expressed in conventional T cells. In addition to promoting Treg lineage stability, RelA determines the size of the effector Treg population, a function influenced by the presence or absence of RelA in conventional T cells. These findings showing that RelA controls Treg stability and promotes the competitive fitness of effector Tregs highlight the importance of RelA activity in peripheral Treg induced tolerance.
- Publisher
- Elsevier
- Research Division(s)
- Molecular Genetics Of Cancer
- PubMed ID
- 27068879
- Publisher's Version
- https://doi.org/10.1016/j.jaut.2016.03.017
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2016-04-28 02:06:57
Last Modified: 2016-05-02 08:37:40