Regulation of platelet lifespan by apoptosis
Author(s)
Lebois, M; Josefsson, EC;
Details
Publication Year 2016-04-21, Volume 14, Issue #9, Page 1882-1887
Journal Title
Platelets
Publication Type
Journal Article
Abstract
The lifespan of platelets in circulation is brief, close to 10 days in humans and 5 days in mice. Bone marrow residing megakaryocytes produce around 100 billion platelets per day. In a healthy individual, the majority of platelets are not consumed by hemostatic processes, but rather their lifespan is controlled by programmed cell death, a canonical intrinsic apoptosis program. In the last decade, insights from genetically manipulated mouse models and pharmacological developments have helped to define the components of the intrinsic, or mitochondrial, apoptosis pathway that controls platelet lifespan. This review focuses on the molecular regulation of apoptosis in platelet survival, reviews thrombocytopenic conditions linked to enhanced platelet death, examines implications of chemotherapy-induced thrombocytopenia through apoptosis-inducing drugs in cancer therapy as well as discusses ex vivo aging of platelets.
Publisher
Taylor & Francis
WEHI Research Division(s)
Cancer And Haematology
PubMed ID
27100842
NHMRC Grants
NHMRC/1079250 NHMRC/1016647
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2016-05-02 10:21:20
Last Modified: 2018-07-05 09:23:23
An error has occurred. This application may no longer respond until reloaded. Reload 🗙