Patient-derived xenograft (PDX) models in basic and translational breast cancer research
Details
Publication Year 2016-12, Volume 35, Issue #4, Page 547-573
Journal Title
Cancer Metastasis Rev
Publication Type
Journal Article
Abstract
Patient-derived xenograft (PDX) models of a growing spectrum of cancers are rapidly supplanting long-established traditional cell lines as preferred models for conducting basic and translational preclinical research. In breast cancer, to complement the now curated collection of approximately 45 long-established human breast cancer cell lines, a newly formed consortium of academic laboratories, currently from Europe, Australia, and North America, herein summarizes data on over 500 stably transplantable PDX models representing all three clinical subtypes of breast cancer (ER+, HER2+, and "Triple-negative" (TNBC)). Many of these models are well-characterized with respect to genomic, transcriptomic, and proteomic features, metastatic behavior, and treatment response to a variety of standard-of-care and experimental therapeutics. These stably transplantable PDX lines are generally available for dissemination to laboratories conducting translational research, and contact information for each collection is provided. This review summarizes current experiences related to PDX generation across participating groups, efforts to develop data standards for annotation and dissemination of patient clinical information that does not compromise patient privacy, efforts to develop complementary data standards for annotation of PDX characteristics and biology, and progress toward "credentialing" of PDX models as surrogates to represent individual patients for use in preclinical and co-clinical translational research. In addition, this review highlights important unresolved questions, as well as current limitations, that have hampered more efficient generation of PDX lines and more rapid adoption of PDX use in translational breast cancer research.
Publisher
Springer
WEHI Research Division(s)
Stem Cells And Cancer
PubMed ID
28025748
NHMRC Grants
NHMRC/1078730 NHMRC/1037230
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2017-05-26 03:48:48
Last Modified: 2017-05-26 03:51:25
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