Transcriptional regulation of tissue-resident lymphocytes
- Author(s)
- Mackay, LK; Kallies, A;
- Details
- Publication Year 2017-12-08,Volume 38,Issue #2,Page 94-103
- Journal Title
- Trends Immunol
- Publication Type
- Journal Article
- Abstract
- Numerous innate and adaptive immune cells reside in non-lymphoid tissues, where they contribute to barrier immunity, tissue homeostasis, and immune regulation. These tissue-resident populations do not recirculate in the blood or lymphatics and adopt a unique phenotype that is distinct from immune cells in the circulation. Tissue residency has been predominantly described for memory CD8+ T cells [tissue-resident memory T cells (TRM)], but it is now clear that CD4 T cells, regulatory T (Treg) cells, various innate T cells, and innate lymphoid cells (ILCs) can establish residence in non-lymphoid tissues. Here we highlight distinct and common features of tissue-resident lymphocytes, with a focus on the transcriptional programs that have recently been shown to guide the establishment of tissue residency.
- Publisher
- Cell Press
- Research Division(s)
- Molecular Immunology
- PubMed ID
- 27939451
- Publisher's Version
- https://doi.org/10.1016/j.it.2016.11.004
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2017-05-26 03:11:45
Last Modified: 2017-05-26 03:38:43