Nasal-associated lymphoid tissues (NALTs) support the recall but not priming of influenza virus-specific cytotoxic T cells
- Author(s)
- Pizzolla, A; Wang, Z; Groom, JR; Kedzierska, K; Brooks, AG; Reading, PC; Wakim, LM;
- Details
- Publication Year 2017-05-01,Volume 114,Issue #20,Page 5225-5230
- Journal Title
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type
- Journal Article
- Abstract
- The lymphoid tissue that drains the upper respiratory tract represents an important induction site for cytotoxic T lymphocyte (CTL) immunity to airborne pathogens and intranasal vaccines. Here, we investigated the role of the nasal-associated lymphoid tissues (NALTs), which are mucosal-associated lymphoid organs embedded in the submucosa of the nasal passage, in the initial priming and recall expansion of CD8+ T cells following an upper respiratory tract infection with a pathogenic influenza virus and immunization with a live attenuated influenza virus vaccine. Whereas NALTs served as the induction site for the recall expansion of memory CD8+ T cells following influenza virus infection or vaccination, they failed to support activation of naive CD8+ T cells. Strikingly, NALTs, unlike other lymphoid tissues, were not routinely surveyed during the steady state by circulating T cells. The selective recruitment of memory T cells into these lymphoid structures occurred in response to infection-induced elevation of the chemokine CXCL10, which attracted CXCR3+ memory CD8+ T cells. These results have significant implications for intranasal vaccines, which deliver antigen to mucosal-associated lymphoid tissue and aim to elicit protective CTL-mediated immunity.
- Publisher
- Rockefeler Uni Press
- Research Division(s)
- Molecular Immunology
- PubMed ID
- 28461487
- Publisher's Version
- https://doi.org/10.1073/pnas.1620194114
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2017-05-15 01:16:27
Last Modified: 2017-09-12 11:58:23