Granzyme K-deficient mice show no evidence of impaired anti-viral immunity
- Author(s)
- Joeckel, LT; Allison, CC; Pellegrini, M; Bird, CH; Bird, PI;
- Details
- Publication Year 2017-09,Volume 95,Issue #8,Page 675-683
- Journal Title
- Immunol Cell Biol
- Publication Type
- Journal Article
- Abstract
- The biological role of granzyme K, a serine protease of cytotoxic T lymphocytes (CTL), is controversial. It has been reported to induce perforin-mediated cell death in vitro, but is also reported to be non-cytotoxic and to operate in inflammatory processes. To elucidate the biological role of this protease we have deleted the granzyme K gene in mice (mutant allele: Gzmktm1.1Pib; MGI:5636646). Gzmk-/- mice are healthy, anatomically normal, fecund, and show normal hematopoietic development. Gzmk-/- mice readily recover from Lymphocytic choriomeningitis virus and mouse pox Ectromelia virus infection. Ex vivo, virus-specific granzyme K-deficient CTL are indistinguishable from those of wild type mice in apoptosis induction of target cells. These data suggest that granzyme K does not play an essential role in viral immunity or cytotoxicity. Our granzyme K knockout line completes the collection of mouse models for the human granzymes, and will further our understanding of their biological roles and relationships.Immunology and Cell Biology accepted article preview online, 21 April 2017. doi:10.1038/icb.2017.35.
- Publisher
- Springer Nature
- Research Division(s)
- Infection And Immunity
- PubMed ID
- 28428612
- Publisher's Version
- https://doi.org/10.1038/icb.2017.35
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2017-05-02 03:01:27
Last Modified: 2018-05-04 02:47:59