Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo
- Author(s)
- Carrington, EM; Zhan, Y; Brady, JL; Zhang, JG; Sutherland, RM; Anstee, NS; Schenk, RL; Vikstrom, IB; Delconte, RB; Segal, D; Huntington, ND; Bouillet, P; Tarlinton, DM; Huang, DC; Strasser, A; Cory, S; Herold, MJ; Lew, AM;
- Details
- Publication Year 2017-05,Volume 24,Issue #5,Page 878-888
- Journal Title
- Cell Death and Differentiation
- Publication Type
- Journal Article
- Abstract
- Survival of various immune cell populations has been proposed to preferentially rely on a particular anti-apoptotic BCL-2 family member, for example, naive T cells require BCL-2, while regulatory T cells require MCL-1. Here we examined the survival requirements of multiple immune cell subsets in vitro and in vivo, using both genetic and pharmacological approaches. Our findings support a model in which survival is determined by quantitative participation of multiple anti-apoptotic proteins rather than by a single anti-apoptotic protein. This model provides both an insight into how the sum of relative levels of anti-apoptotic proteins BCL-2, MCL-1 and A1 influence survival of T cells, B cells and dendritic cells, and a framework for ascertaining how these different immune cells can be optimally targeted in treatment of immunopathology, transplantation rejection or hematological cancers.Cell Death and Differentiation advance online publication, 31 March 2017; doi:10.1038/cdd.2017.30.
- Publisher
- Springer Nature
- Research Division(s)
- Immunology; Cancer And Haematology; Molecular Genetics Of Cancer; Molecular Immunology
- PubMed ID
- 28362427
- Publisher's Version
- https://doi.org/10.1038/cdd.2017.30
- NHMRC Grants
- NHMRC/1037321, NHMRC/1043414, NHMRC/1080321, NHMRC/1105209, NHMRC/461221, NHMRC/1042629, NHMRC/1020363, NHMRC/1016701, NHMRC/1054925, NHMRC/1060675, NHMRC/1016647, NHMRC/1049720,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2017-05-02 03:01:23
Last Modified: 2018-05-03 03:27:57