The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation
Journal Title
Semin Cell Dev Biol
Publication Type
Journal Article in press
Abstract
Apoptosis is a form of programmed cell death critical for the development and homeostasis of multicellular organisms. A key event within the mitochondrial pathway to apoptosis is the permeabilisation of the mitochondrial outer membrane (MOM), a point of no return in apoptotic progression. This event is governed by a complex interplay of interactions between BCL-2 family members. Here we discuss the roles of opposing factions within the family. We focus on the structural details of these interactions, how they promote or prevent apoptosis and recent developments towards understanding the conformational changes of BAK and BAX that lead to MOM permeabilisation. These interactions and structural insights are of particular interest for drug discovery, as highlighted by the development of therapeutics that target pro-survival family members and restore apoptosis in cancer cells.
Publisher
Elsevier
WEHI Research Division(s)
Structural Biology
PubMed ID
28396106
NHMRC Grants
NHMRC/1059331 NHMRC/1079706 NHMRC/1079700
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2017-05-02 03:01:35
Last Modified: 2017-05-09 11:09:40
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