Screening the MMV Pathogen Box across multiple pathogens reclassifies starting points for open source drug discovery

Duffy, S; Sykes, ML; Jones, AJ; Shelper, TB; Simpson, M; LANG, R; Poulsen, SA; Sleebs, BE; Avery, VM

Author(s): Duffy, S; Sykes, ML; Jones, AJ; Shelper, TB; Simpson, M; LANG, R; Poulsen, SA; Sleebs, BE; Avery, VM;
Details: Publication Year 2017-08-24,Volume 61,Issue #9,Page e00379-17
Journal Title: Antimicrob Agents Chemother
Publication Type: Journal Article
Abstract: Open access drug discovery provides a substantial resource for diseases primarily affecting the poor and disadvantaged. The open access Pathogen Box is comprised of a collection of compounds with demonstrated biological activity against specific pathogenic organisms. The supply of this resource by the Medicines for Malaria Venture has the potential to provide new chemical starting points for a number of tropical and neglected diseases, through repurposing of these compounds for use in drug discovery campaigns for these additional pathogens. Here we have tested the Pathogen Box against kinetoplastid parasites and malaria life cycle stages in vitro Consequently, chemical starting points for malaria, human African trypanosomiasis, Chagas disease and leishmaniasis drug discovery efforts have been identified. Inclusive of this in vitro biological evaluation, outcomes from extensive literature reviews and database searches are provided. This information encompasses commercial availability, literature reference citations, other aliases and ChEMBL number with associated biological activity, where available. The release of this new data for the Pathogen Box collection into the public domain will aid the open source model of drug discovery. Importantly, this will provide novel chemical starting points for drug discovery and target identification in tropical disease research.
Publisher: ASM
Research Division(s): Chemical Biology
PubMed ID: 28674055
Publisher's Version: https://doi.org/10.1128/AAC.00379-17
Open Access at Publisher's Site: https://doi.org/10.1128/AAC.00379-17
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2017-07-26 12:48:11

Last Modified: 2018-05-03 03:21:53