Natural immune response to Plasmodium vivax alpha-helical coiled coil protein motifs and its association with the risk of P. vivax malaria
- Author(s)
- Cespedes, N; Li Wai Suen, CSN; Koepfli, C; Franca, CT; Felger, I; Nebie, I; Arevalo-Herrera, M; Mueller, I; Corradin, G; Herrera, S;
- Details
- Publication Year 2017,Volume 12,Issue #6,Page e0179863
- Journal Title
- PLoS One
- Publication Type
- Journal Article
- Abstract
- Protein alpha-helical coiled coil structures are known to induce antibodies able to block critical functions in different pathogens. In a previous study, a total of 50 proteins of Plasmodium vivax erythrocytic asexual stages containing alpha-helical coiled coil structural motifs were identified in silico, and the corresponding peptides were chemically synthesized. A total of 43 peptides were recognized by naturally acquired antibodies in plasma samples from both Papua New Guinea (PNG) and Colombian adult donors. In this study, the association between IgG antibodies to these peptides and clinical immunity was further explored by measuring total IgG antibody levels to 24 peptides in baseline samples from a longitudinal study of children aged 1-3 years (n = 164) followed for 16 months. Samples were reactive to all peptides tested. Eight peptides were recognized by >50% of individuals, whereas only one peptide had < 20% reactivity. Children infected at baseline were seropositive to 23/24 peptides. No significant association was observed between antibody titers and age or molecular force of infection, suggesting that antibody levels had already reached an equilibrium. There was a strong association between antibody levels to all peptides and protection against P. vivax clinical episodes during the 16 months follow-up. These results suggest that the selected coiled coil antigens might be good markers of both exposure and acquired immunity to P. vivax malaria, and further preclinical investigation should be performed to determine their potential as P. vivax vaccine antigens.
- Publisher
- PLOS
- Research Division(s)
- Population Health And Immunity
- PubMed ID
- 28651021
- Publisher's Version
- https://doi.org/10.1371/journal.pone.0179863
- Open Access at Publisher's Site
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Creation Date: 2017-07-26 12:48:10
Last Modified: 2017-07-26 02:47:55