Standing out from the crowd: How to identify plasma cells
- Author(s)
- Tellier, J; Nutt, SL;
- Details
- Publication Year 2017-08,Volume 47,Issue #8,Page 1276-1279
- Journal Title
- European Journal of Immunology
- Publication Type
- Journal Article
- Abstract
- Being the sole source of antibody, plasmablasts and plasma cells are essential for protective immunity. Due to their relative rarity, heterogeneity and the loss of many canonical B-cell markers, antibody-secreting cells (ASCs) have often been problematic to identify and further characterize. In the mouse, the combination of the expression of CD138 and BLIMP-1, has led to many insights into ASC biology, although this approach requires the use of a GFP reporter strain. In the current issue of the European Journal of Immunology, two independent studies by Wilmore et al. and Pracht et al. provide alternative approaches to identify all murine ASCs using antibodies against the cell surface proteins, Sca-1 and TACI, respectively. Here we will discuss the advantages of these new approaches to identify ASCs in the context of our emerging knowledge of the cell surface phenotype and gene expression program of various ASC subsets in the murine and human systems.
- Publisher
- Wiley
- Research Division(s)
- Molecular Immunology
- PubMed ID
- 28787106
- Publisher's Version
- https://doi.org/10.1002/eji.201747168
- NHMRC Grants
- NHMRC/1054925,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2017-08-30 02:22:19
Last Modified: 2017-09-04 01:34:14