The molecular basis of erythrocyte invasion by malaria parasites
- Author(s)
- Cowman, AF; Tonkin, CJ; Tham, WH; Duraisingh, MT;
- Details
- Publication Year 2017-08-09,Volume 22,Issue #2,Page 232-245
- Journal Title
- Cell Host Microbe
- Publication Type
- Journal Article
- Abstract
- Plasmodium species cause malaria by proliferating in human erythrocytes. Invasion of immunologically privileged erythrocytes provides a relatively protective niche as well as access to a rich source of nutrients. Plasmodium spp. target erythrocytes of different ages, but share a common mechanism of invasion. Specific engagement of erythrocyte receptors defines target cell tropism, activating downstream events and resulting in the physical penetration of the erythrocyte, powered by the parasite's actinomyosin-based motor. Here we review the latest in our understanding of the molecular composition of this highly complex and fascinating biological process.
- Publisher
- Cell Press
- Research Division(s)
- Infection And Immunity
- PubMed ID
- 28799908
- Publisher's Version
- https://doi.org/10.1016/j.chom.2017.07.003
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2017-08-30 02:22:17
Last Modified: 2017-09-04 01:24:17