PTPN2 regulates T cell lineage commitment and alphabeta versus gammadelta specification
- Author(s)
- Wiede, F; Dudakov, JA; Lu, KH; Dodd, GT; Butt, T; Godfrey, DI; Strasser, A; Boyd, RL; Tiganis, T;
- Journal Title
- J Exp Med
- Publication Type
- Journal Article in press
- Abstract
- In the thymus, hematopoietic progenitors commit to the T cell lineage and undergo sequential differentiation to generate diverse T cell subsets, including major histocompatibility complex (MHC)-restricted alphabeta T cell receptor (TCR) T cells and non-MHC-restricted gammadelta TCR T cells. The factors controlling precursor commitment and their subsequent maturation and specification into alphabeta TCR versus gammadelta TCR T cells remain unclear. Here, we show that the tyrosine phosphatase PTPN2 attenuates STAT5 (signal transducer and activator of transcription 5) signaling to regulate T cell lineage commitment and SRC family kinase LCK and STAT5 signaling to regulate alphabeta TCR versus gammadelta TCR T cell development. Our findings identify PTPN2 as an important regulator of critical checkpoints that dictate the commitment of multipotent precursors to the T cell lineage and their subsequent maturation into alphabeta TCR or gammadelta TCR T cells.
- Publisher
- Rockefeler Uni Press
- Research Division(s)
- Molecular Genetics Of Cancer
- PubMed ID
- 28798028
- Publisher's Version
- https://doi.org/10.1084/jem.20161903
- NHMRC Grants
- NHMRC/1016701, NHMRC/1020363,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2017-08-30 02:22:14
Last Modified: 2017-09-04 01:16:30