Targeting apoptotic pathways to treat lymphoid malignancies
- Author(s)
- Roberts, Andrew W;
- Details
- Publication Year 2016,Volume 57,Issue #10,Page 2054-2058
- Journal Title
- Rinsho Ketsueki: Jap J Clin Hematol
- Publication Type
- Journal Article
- Abstract
- Oncogenic transformation through activation of proliferation generates cellular stress which promotes apoptosis, thereby diminishing the growth advantage of cancerous cells over normal cells. Consequently, many haematological malignancies also harbour aberrations that circumvent apoptosis, with aberrations of TP53 and the BCL2 family being the most common. This educational lecture focuses on current understanding of the role of the intrinsic pathway to apoptosis in lymphoid cancers, its regulation by BCL2 and related proteins, and emerging data on the therapeutic potential of inhibiting BCL2 to induce apoptosis in BCL2-expressing B cell cancers.
- Publisher
- Japanese Society of Hematology
- Research Division(s)
- Cancer And Haematology
- Publisher's Version
- https://doi.org/10.11406/rinketsu.57.2054
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2017-05-26 03:48:55
Last Modified: 2017-05-26 04:11:02