The JAK–STAT–SOCS signaling cascade
- Author(s)
- Murphy, JM; Babon, JJ; Nicola, NA; Nicholson, SE;
- Journal Title
- Encyclopedia of Cell Biology
- Publication Type
- Book Section
- Abstract
- Abstract The JAK–STAT pathway is the central intracellular signal transduction cascade initiated by ligand binding to numerous growth factor and cytokine receptors, and since its discovery two decades ago it has been the subject of extensive investigation. The pathway is negatively regulated by the SOCS family proteins, which restrict the extent of the cytokine response, thus preventing excessive and deleterious inflammatory and immune signaling. There are now many examples of human mutations and disease conditions where the JAK–STAT–SOCS axis is perturbed, and we have witnessed the advent of JAK inhibitors in the clinic. This review explores our current understanding of how this unique pathway functions.
- Publisher
- Academic Press Elsevier
- Research Division(s)
- Cancer And Haematology; Inflammation; Structural Biology; Cell Signalling And Cell Death
- Publisher's Version
- https://doi.org/http://dx.doi.org/10.1016/B978-0-12-394447-4.30016-5
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2017-05-26 03:48:53
Last Modified: 2017-05-26 04:06:35