STAT3 signaling mediates tumour resistance to EGFR targeted therapeutics
Journal Title
Mol Cell Endocrinol
Publication Type
Journal Article in press
Abstract
Several EGFR inhibitors are currently undergoing clinical assessment or are approved for the clinical management of patients with varying tumour types. However, treatment often results in a lack of response in many patients. The majority of patients that initially respond eventually present with tumours that display acquired resistance to the original therapy. A large number of receptor tyrosine and intracellular kinases have been implicated in driving signaling that mediates this tumour resistance to anti-EGFR targeted therapy, and in a few cases these discoveries have led to overall changes in prospective tumour screening and clinical practice (K-RAS in mCRC and EGFR T790M in NSCLC). In this mini-review, we specifically focus on the role of the STAT3 signaling axis in providing both intrinsic and acquired resistance to inhibitors of the EGFR. We also focus on STAT3 pathway targeting in an attempt to overcome resistance to anti-EGFR therapeutics.
Publisher
Elsevier
WEHI Research Division(s)
Inflammation
PubMed ID
28088467
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2017-04-06 09:27:11
Last Modified: 2017-04-10 10:09:50
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