Dysregulation of histone methyltransferases in breast cancer - Opportunities for new targeted therapies?
- Author(s)
- Michalak, EM; Visvader, JE;
- Details
- Publication Year 2016-12,Volume 10,Issue #10,Page 1497-1515
- Journal Title
- Mol Oncol
- Publication Type
- Journal Article
- Abstract
- Histone methyltransferases (HMTs) catalyze the methylation of lysine and arginine residues on histone tails and non-histone targets. These important post-translational modifications are exquisitely regulated and affect chromatin compaction and transcriptional programs leading to diverse biological outcomes. There is accumulating evidence that genetic alterations of several HMTs impinge on oncogenic or tumor-suppressor functions and influence both cancer initiation and progression. HMTs therefore represent an opportunity for therapeutic targeting in those patients with tumors in which HMTs are dysregulated, to reverse the histone marks and transcriptional programs associated with aggressive tumor behavior. In this review, we describe the known histone methyltransferases and their emerging roles in breast cancer tumorigenesis.
- Publisher
- Wiley
- Research Division(s)
- Stem Cells And Cancer
- PubMed ID
- 27717710
- Publisher's Version
- https://doi.org/10.1016/j.molonc.2016.09.003
- Open Access at Publisher's Site
http://onlinelibrary.wiley.com/doi/10.1016/j.molonc.2016.09.003/full- NHMRC Grants
- NHMRC/1016701, NHMRC/1086727,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2016-10-19 11:52:30
Last Modified: 2017-09-29 12:04:34