Transcription factor T-bet orchestrates lineage development and function in the immune system
- Author(s)
- Kallies, A; Good-Jacobson, KL;
- Details
- Publication Year 2017-04,Volume 38,Issue #4,Page 287-297
- Journal Title
- Trends Immunol
- Publication Type
- Journal Article
- Abstract
- T-bet was originally described as the key transcription factor defining type 1 T helper (Th) cells. However, it is now clear that it drives the orchestrated generation of effector and memory cells in multiple different lymphocyte lineages. In addition to Th1 cells, CD8 T cells, B cells and some innate lymphocyte populations require T-bet for their development or differentiation in response to antigen. Furthermore, other Th cell populations, including T follicular helper and Th17, as well as regulatory T cells can co-opt T-bet expression to promote functional diversification and colocalization. Thus, T-bet broadly regulates transcriptional programs in response to type 1 inflammatory signals and mediates the coordinated differentiation, function, migration and survival of effector and memory lymphocyte subsets in the affected tissue. Therefore, T-bet expression is essential for effective clearance of pathogens and maintenance of immunity.
- Publisher
- Cell Press
- Research Division(s)
- Molecular Immunology
- PubMed ID
- 28279590
- Publisher's Version
- https://doi.org/10.1016/j.it.2017.02.003
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2017-04-12 10:42:08
Last Modified: 2017-04-12 10:50:23