Transcription factor T-bet orchestrates lineage development and function in the immune system
Details
Publication Year 2017-04, Volume 38, Issue #4, Page 287-297
Journal Title
Trends Immunol
Publication Type
Journal Article
Abstract
T-bet was originally described as the key transcription factor defining type 1 T helper (Th) cells. However, it is now clear that it drives the orchestrated generation of effector and memory cells in multiple different lymphocyte lineages. In addition to Th1 cells, CD8 T cells, B cells and some innate lymphocyte populations require T-bet for their development or differentiation in response to antigen. Furthermore, other Th cell populations, including T follicular helper and Th17, as well as regulatory T cells can co-opt T-bet expression to promote functional diversification and colocalization. Thus, T-bet broadly regulates transcriptional programs in response to type 1 inflammatory signals and mediates the coordinated differentiation, function, migration and survival of effector and memory lymphocyte subsets in the affected tissue. Therefore, T-bet expression is essential for effective clearance of pathogens and maintenance of immunity.
Publisher
Cell Press
WEHI Research Division(s)
Molecular Immunology
PubMed ID
28279590
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2017-04-12 10:42:08
Last Modified: 2017-04-12 10:50:23
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