Genomic characterisation of Emu-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene
- Author(s)
- Lefebure, M; Tothill, RW; Kruse, E; Hawkins, ED; Shortt, J; Matthews, GM; Gregory, GP; Martin, BP; Kelly, MJ; Todorovski, I; Doyle, MA; Lupat, R; Li, J; Schroeder, J; Wall, M; Craig, S; Poortinga, G; Cameron, D; Bywater, M; Kats, L; Gearhart, MD; Bardwell, VJ; Dickins, RA; Hannan, RD; Papenfuss, AT; Johnstone, RW;
- Journal Title
- Nat Commun
- Publication Type
- Journal Article
- Abstract
- The Emu-Myc mouse is an extensively used model of MYC driven malignancy; however to date there has only been partial characterization of MYC co-operative mutations leading to spontaneous lymphomagenesis. Here we sequence spontaneously arising Emu-Myc lymphomas to define transgene architecture, somatic mutations, and structural alterations. We identify frequent disruptive mutations in the PRC1-like component and BCL6-corepressor gene Bcor. Moreover, we find unexpected concomitant multigenic lesions involving Cdkn2a loss and other cancer genes including Nras, Kras and Bcor. These findings challenge the assumed two-hit model of Emu-Myc lymphoma and demonstrate a functional in vivo role for Bcor in suppressing tumorigenesis.
- Publisher
- Springer Nature
- Research Division(s)
- Immunology; Bioinformatics
- PubMed ID
- 28262675
- Publisher's Version
- https://doi.org/10.1038/ncomms14581
- Open Access at Publisher's Site
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- Refer to copyright notice on published article.
Creation Date: 2017-04-12 10:42:10
Last Modified: 2017-04-12 11:02:05