Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment
- Author(s)
- Schenk, RL; Tuzlak, S; Carrington, EM; Zhan, Y; Heinzel, S; Teh, CE; Gray, DH; Tai, L; Lew, AM; Villunger, A; Strasser, A; Herold, MJ;
- Details
- Publication Year 2017-03,Volume 24,Issue #3,Page 534-545
- Journal Title
- Cell Death and Differentiation
- Publication Type
- Journal Article
- Abstract
- The pro-survival proteins of the BCL-2 family regulate the survival of all cells, and genetic deletion models for these proteins have revealed which specific BCL-2 family member(s) is/are critical for the survival of particular cell types. A1 is a pro-survival BCL-2-like protein that is expressed predominantly in haematopoietic cells, and here we describe the characterisation of a novel mouse strain that lacks all three functional isoforms of A1 (A1-a, A1-b and A1-d). Surprisingly, complete loss of A1 caused only minor defects, with significant, although relatively small, decreases in gammadeltaTCR T cells, antigen-experienced conventional as well as regulatory CD4 T cells and conventional dendritic cells (cDCs). When examining these cell types in tissue culture, only cDC survival was significantly impaired by the loss of A1. Therefore, A1 appears to be a surprisingly redundant pro-survival protein in the haematopoietic system and other tissues, suggesting that its targeting in cancer may be readily tolerated.
- Publisher
- Springer Nature
- Research Division(s)
- Molecular Genetics Of Cancer; Immunology
- PubMed ID
- 28085150
- Publisher's Version
- https://doi.org/10.1038/cdd.2016.156
- NHMRC Grants
- NHMRC/1016701, NHMRC/1020363, NHMRC/1049720,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2017-04-12 10:42:22
Last Modified: 2017-04-12 11:33:11