Suppressor of Cytokine Signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling
Journal Title
Elife
Publication Type
Journal Article
Abstract
Influenza virus infections have a significant impact on global human health. Individuals with suppressed immunity, or suffering from chronic inflammatory conditions such as COPD, are particularly susceptible to influenza. Here we show that suppressor of cytokine signaling (SOCS) 5 has a pivotal role in restricting influenza A virus in the airway epithelium, through the regulation of epidermal growth factor receptor (EGFR). Socs5-deficient mice exhibit heightened disease severity, with increased viral titres and weight loss. Socs5 levels were differentially regulated in response to distinct influenza viruses (H1N1, H3N2, H5N1 and H11N9) and were reduced in primary epithelial cells from COPD patients, again correlating with increased susceptibility to influenza. Importantly, restoration of SOCS5 levels restricted influenza virus infection, suggesting that manipulating SOCS5 expression and/or SOCS5 targets might be a novel therapeutic approach to influenza.
Publisher
eLIFE
WEHI Research Division(s)
Structural Biology; Molecular Immunology; Cancer And Haematology; Systems Biology And Personalised Medicine; Inflammation
PubMed ID
28195529
Open Access at Publisher's Site
https://elifesciences.org/content/6/e20444
NHMRC Grants
NHMRC/1045762 NHMRC/1016647
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2017-04-06 09:27:37
Last Modified: 2017-04-07 03:19:39
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