T cell responses in the central nervous system
- Author(s)
- Korn, T; Kallies, A;
- Details
- Publication Year 2017-03,Volume 17,Issue #3,Page 179-194
- Journal Title
- Nat Rev Immunol
- Publication Type
- Journal Article
- Abstract
- T cells are required for immune surveillance of the central nervous system (CNS); however, they can also induce severe immunopathology in the context of both viral infections and autoimmunity. The mechanisms that are involved in the priming and recruitment of T cells to the CNS are only partially understood, but there has been renewed interest in this topic since the 'rediscovery' of lymphatic drainage from the CNS. Moreover, tissue-resident memory T cells have been detected in the CNS and are increasingly recognized as an autonomous line of host defence. In this Review, we highlight the main mechanisms that are involved in the priming and CNS recruitment of CD4+ T cells, CD8+ T cells and regulatory T cells. We also consider the plasticity of T cell responses in the CNS, with a focus on viral infection and autoimmunity.
- Publisher
- Springer Nature
- Research Division(s)
- Molecular Immunology
- PubMed ID
- 28138136
- Publisher's Version
- https://doi.org/10.1038/nri.2016.144
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2017-04-06 09:27:35
Last Modified: 2017-04-06 11:13:59