VHL: Cullin-g the hypoxic response
- Author(s)
- Kershaw, NJ; Babon, JJ;
- Details
- Publication Year 2015-03-03,Volume 23,Issue #3,Page 435-436
- Journal Title
- Structure
- Publication Type
- Journal Article
- Abstract
- Hypoxia inducible factor (HIF)-mediated response to hypoxic conditions is turned off by VHL-mediated ubiquitination of HIFalpha. To achieve this, VHL binds HIFalpha and recruits it to a specific E3 ubiquitin ligase complex, a Cullin-RING-ligase. In this issue of Structure, Nyugen et al. provide a structural view of how VHL engages the ligase in order to inhibit the hypoxic response.
- Publisher
- Cell Press
- Research Division(s)
- Structural Biology
- PubMed ID
- 25738382
- Publisher's Version
- https://doi.org/10.1016/j.str.2015.02.003
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2015-03-06 11:41:45
Last Modified: 2016-04-20 11:47:59