IAP gene deletion and conditional knockout models
- Journal Title
- Semin Cell Dev Biol
- Publication Type
- Journal Article
- Abstract
- Gene deletion studies have helped reveal the unique and overlapping roles played by IAP proteins. Crossing IAP mutant mice has helped unravel the complex feed-back regulatory circuits in which cIAP1, cIAP2 and XIAP allow innate defensive responses to microbial pathogens, without the development of auto-inflammatory syndromes. Deletion of genes for Survivin and its homologs in yeasts, invertebrates and mammals has shown that it functions differently, as it is not a regulator of innate immunity or apoptosis, but acts together with INCENP, aurora kinase B and Borealin to allow chromosome segregation during mitosis.
- Publisher
- Elsevier
- Keywords
- IAP; Gene deletion; BIR; Birc; Survivin; NAIP; Knock out mouse
- Research Division(s)
- Cell Signalling And Cell Death
- Publisher's Version
- https://doi.org/10.1016/j.semcdb.2014.12.004
- NHMRC Grants
- NHMRC/596822, NHMRC/541902, NHMRC/1016701,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2015-01-08 01:33:39
Last Modified: 2016-02-24 01:50:46