The generation of antibody-secreting plasma cells
Details
Publication Year 2015-03, Volume 15, Issue #3, Page 160-71
Journal Title
Nat Rev Immunol
Publication Type
Journal Article
Abstract
The regulation of antibody production is linked to the generation and maintenance of plasmablasts and plasma cells from their B cell precursors. Plasmablasts are the rapidly produced and short-lived effector cells of the early antibody response, whereas plasma cells are the long-lived mediators of lasting humoral immunity. An extraordinary number of control mechanisms, at both the cellular and molecular levels, underlie the regulation of this essential arm of the immune response. Despite this complexity, the terminal differentiation of B cells can be described as a simple probabilistic process that is governed by a central gene-regulatory network and modified by environmental stimuli.
Publisher
NPG
WEHI Research Division(s)
Molecular Immunology; Immunology
PubMed ID
25698678
Publisher's Version
https://doi.org/10.1038/nri3795
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2015-02-25 01:47:26
Last Modified: 2015-09-07 03:32:23
An error has occurred. This application may no longer respond until reloaded. Reload 🗙