The generation of antibody-secreting plasma cells
- Author(s)
- Nutt, SL; Hodgkin, PD; Tarlinton, DM; Corcoran, LM;
- Details
- Publication Year 2015-03,Volume 15,Issue #3,Page 160-71
- Journal Title
- Nat Rev Immunol
- Publication Type
- Journal Article
- Abstract
- The regulation of antibody production is linked to the generation and maintenance of plasmablasts and plasma cells from their B cell precursors. Plasmablasts are the rapidly produced and short-lived effector cells of the early antibody response, whereas plasma cells are the long-lived mediators of lasting humoral immunity. An extraordinary number of control mechanisms, at both the cellular and molecular levels, underlie the regulation of this essential arm of the immune response. Despite this complexity, the terminal differentiation of B cells can be described as a simple probabilistic process that is governed by a central gene-regulatory network and modified by environmental stimuli.
- Publisher
- NPG
- Research Division(s)
- Molecular Immunology; Immunology
- PubMed ID
- 25698678
- Publisher's Version
- https://doi.org/10.1038/nri3795
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2015-02-25 01:47:26
Last Modified: 2015-09-07 03:32:23