Results of a phase 2 study of pacritinib (SB1518), a JAK2/JAK2(V617F) inhibitor, in patients with myelofibrosis

Komrokji, RS; Seymour, JF; Roberts, AW; Wadleigh, M; To, LB; Scherber, R; Turba, E; Dorr, A; Zhu, J; Wang, L; Granston, T; Campbell, MS; Mesa, RA

Author(s): Komrokji, RS; Seymour, JF; Roberts, AW; Wadleigh, M; To, LB; Scherber, R; Turba, E; Dorr, A; Zhu, J; Wang, L; Granston, T; Campbell, MS; Mesa, RA;
Details: Publication Year 2015-04-23,Volume 125,Issue #17,Page 2649-55
Journal Title: Blood
Publication Type: Journal Article
Abstract: Pacritinib (SB1518) is a Janus kinase 2 (JAK2), JAK2(V617F), and Fms-like tyrosine kinase 3 inhibitor that does not inhibit JAK1. It demonstrated a favorable safety profile with promising efficacy in phase 1 studies in patients with primary and secondary myelofibrosis (MF). This multicenter phase 2 study further characterized the safety and efficacy of pacritinib in the treatment of patients with MF. Eligible patients had clinical splenomegaly poorly controlled with standard therapies or were newly diagnosed with intermediate- or high-risk Lille score. Patients with any degree of cytopenia were eligible. Thirty-five patients were enrolled. At entry, 40% had hemoglobin <10 g/dL and 43% had platelets <100 000x 10(9)/L. Up to week 24, 8 of 26 evaluable patients (31%) achieved a >/=35% decrease in spleen volume determined by magnetic resonance imaging and 14 of 33 (42%) attained a >/=50% reduction in spleen size by physical examination. Median MF symptom improvement was >/=50% for all symptoms except fatigue. Grade 1 or 2 diarrhea (69%) and nausea (49%) were the most common treatment-emergent adverse events. The study drug was discontinued in 9 patients (26%) due to adverse events (4 severe). Pacritinib is an active agent in patients with MF, offering a potential treatment option for patients with preexisting anemia and thrombocytopenia. This trial was registered at www.clinicaltrials.gov as #NCT00745550.
Publisher: ASH
Research Division(s): Cancer And Haematology
PubMed ID: 25762180
Publisher's Version: https://doi.org/10.1182/blood-2013-02-484832
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2015-05-19 02:05:28

Last Modified: 2016-04-20 12:00:29