The journey from discoveries in fundamental immunology to cancer immunotherapy
- Author(s)
- Miller, JF; Sadelain, M;
- Details
- Publication Year 2015-04-13,Volume 27,Issue #4,Page 439-449
- Journal Title
- Cancer Cell
- Publication Type
- Journal Article
- Abstract
- Recent advances in cancer immunotherapy have directly built on 50 years of fundamental and technological advances that made checkpoint blockade and T cell engineering possible. In this review, we intend to show that research, not specifically designed to bring relief or cure to any particular disease, can, when creatively exploited, lead to spectacular results in the management of cancer. The discovery of thymus immune function, T cells, and immune surveillance bore the seeds for today's targeted immune interventions and chimeric antigen receptors.
- Publisher
- Cell Press
- Research Division(s)
- Immunology
- PubMed ID
- 25858803
- Publisher's Version
- https://doi.org/10.1016/j.ccell.2015.03.007
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2015-05-20 10:11:25
Last Modified: 2016-04-20 12:07:31