DNAM-1 expression marks an alternative program of NK cell maturation
- Author(s)
- Martinet, L; Ferrari De Andrade, L; Guillerey, C; Lee, JS; Liu, J; Souza-Fonseca-Guimaraes, F; Hutchinson, DS; Kolesnik, TB; Nicholson, SE; Huntington, ND; Smyth, MJ;
- Details
- Publication Year 2015-04-07,Volume 11,Issue #1,Page 85-97
- Journal Title
- Cell Rep
- Publication Type
- Journal Article
- Abstract
- Natural killer (NK) cells comprise a heterogeneous population of cells important for pathogen defense and cancer surveillance. However, the functional significance of this diversity is not fully understood. Here, we demonstrate through transcriptional profiling and functional studies that the activating receptor DNAM-1 (CD226) identifies two distinct NK cell functional subsets: DNAM-1(+) and DNAM-1(-) NK cells. DNAM-1(+) NK cells produce high levels of inflammatory cytokines, have enhanced interleukin 15 signaling, and proliferate vigorously. By contrast, DNAM-1(-) NK cells that differentiate from DNAM-1(+) NK cells have greater expression of NK-cell-receptor-related genes and are higher producers of MIP1 chemokines. Collectively, our data reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression.
- Publisher
- Cell Press
- Research Division(s)
- Inflammation; Molecular Immunology
- PubMed ID
- 25818301
- Publisher's Version
- https://doi.org/10.1016/j.celrep.2015.03.006
- Open Access at Publisher's Site
http://www.sciencedirect.com/science/article/pii/S2211124715002594- NHMRC Grants
- NHMRC/1016647, NHMRC/1049407, NHMRC/1066770,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2015-05-20 10:11:24
Last Modified: 2015-05-20 01:19:59