DNAM-1 expression marks an alternative program of NK cell maturation
Details
Publication Year 2015-04-07, Volume 11, Issue #1, Page 85-97
Journal Title
Cell Rep
Publication Type
Journal Article
Abstract
Natural killer (NK) cells comprise a heterogeneous population of cells important for pathogen defense and cancer surveillance. However, the functional significance of this diversity is not fully understood. Here, we demonstrate through transcriptional profiling and functional studies that the activating receptor DNAM-1 (CD226) identifies two distinct NK cell functional subsets: DNAM-1(+) and DNAM-1(-) NK cells. DNAM-1(+) NK cells produce high levels of inflammatory cytokines, have enhanced interleukin 15 signaling, and proliferate vigorously. By contrast, DNAM-1(-) NK cells that differentiate from DNAM-1(+) NK cells have greater expression of NK-cell-receptor-related genes and are higher producers of MIP1 chemokines. Collectively, our data reveal the existence of a functional program of NK cell maturation marked by DNAM-1 expression.
Publisher
Cell Press
WEHI Research Division(s)
Inflammation; Molecular Immunology
PubMed ID
25818301
NHMRC Grants
NHMRC/1016647 NHMRC/1049407 NHMRC/1066770
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2015-05-20 10:11:24
Last Modified: 2015-05-20 01:19:59
An error has occurred. This application may no longer respond until reloaded. Reload 🗙