Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells
- Shi, W; Liao, Y; Willis, SN; Taubenheim, N; Inouye, M; Tarlinton, DM; Smyth, GK; Hodgkin, PD; Nutt, SL; Corcoran, LM;
Publication Year 2015-06, Volume 16, Issue #6, Page 663-673
- Journal Title
- Nat Immunol
- Publication Type
- Journal Article
- When B cells encounter an antigen, they alter their physiological state and anatomical localization and initiate a differentiation process that ultimately produces antibody-secreting cells (ASCs). We have defined the transcriptomes of many mature B cell populations and stages of plasma cell differentiation in mice. We provide a molecular signature of ASCs that highlights the stark transcriptional divide between B cells and plasma cells and enables the demarcation of ASCs on the basis of location and maturity. Changes in gene expression correlated with cell-division history and the acquisition of permissive histone modifications, and they included many regulators that had not been previously implicated in B cell differentiation. These findings both highlight and expand the core program that guides B cell terminal differentiation and the production of antibodies.
- WEHI Research Division(s)
- Bioinformatics; Molecular Immunology; Immunology
- PubMed ID
- Publisher's Version
- Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2015-05-20 09:04:11Last Modified: 2016-01-12 12:35:18