Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells
Details
Publication Year 2015-06, Volume 16, Issue #6, Page 663-673
Journal Title
Nat Immunol
Publication Type
Journal Article
Abstract
When B cells encounter an antigen, they alter their physiological state and anatomical localization and initiate a differentiation process that ultimately produces antibody-secreting cells (ASCs). We have defined the transcriptomes of many mature B cell populations and stages of plasma cell differentiation in mice. We provide a molecular signature of ASCs that highlights the stark transcriptional divide between B cells and plasma cells and enables the demarcation of ASCs on the basis of location and maturity. Changes in gene expression correlated with cell-division history and the acquisition of permissive histone modifications, and they included many regulators that had not been previously implicated in B cell differentiation. These findings both highlight and expand the core program that guides B cell terminal differentiation and the production of antibodies.
Publisher
NPG
WEHI Research Division(s)
Bioinformatics; Molecular Immunology; Immunology
PubMed ID
25894659
Publisher's Version
https://doi.org/10.1038/ni.3154
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2015-05-20 09:04:11
Last Modified: 2016-01-12 12:35:18
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