Moving to the suburbs: T-cell positioning within lymph nodes during activation and memory
- Author(s)
- Groom, JR;
- Details
- Publication Year 2015-03-10,Volume 93,Issue #4,Page 330-336
- Journal Title
- Immunol Cell Biol
- Publication Type
- Journal Article
- Abstract
- Lymph nodes are highly organized secondary lymphoid structures crucial for the initiation of immune responses. Naive T cells are strategically located within lymph nodes to optimize their encounter with antigen-loaded dendritic cells. Recent advances in 3D lymph node imaging and tissue reconstruction along with methods for the detection of chemokine expression and gradients have highlighted how T cells position themselves during activation and memory responses. This article covers new insights into the guidance mechanisms that co-ordinate T-cell responses within draining lymph nodes. Furthering our understanding of how these pathways are regulated and promoted will lead to the exploitation of T-cell positioning to further strategize vaccine design.Immunology and Cell Biology advance online publication, 10 March 2015; doi:10.1038/icb.2015.29.
- Publisher
- NPG
- Research Division(s)
- Molecular Immunology
- PubMed ID
- 25753266
- Publisher's Version
- https://doi.org/10.1038/icb.2015.29
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2015-05-20 10:11:20
Last Modified: 2015-05-20 12:02:39