The structure of human interleukin-11 reveals receptor-binding site features and structural differences from interleukin-6
- Author(s)
- Putoczki, TL; Dobson, RC; Griffin, MD;
- Details
- Publication Year 2014-09-01,Volume 70,Issue #Pt 9,Page 2277-85
- Journal Title
- Acta Crystallogr D Biol Crystallogr
- Publication Type
- Journal Article
- Abstract
- Interleukin (IL)-11 is a multifunctional member of the IL-6 family of cytokines. Recombinant human IL-11 is administered as a standard clinical treatment for chemotherapy-induced thrombocytopaenia. Recently, a new role for IL-11 signalling as a potent driver of gastrointestinal cancers has been identified, and it has been demonstrated to be a novel therapeutic target for these diseases. Here, the crystal structure of human IL-11 is reported and the structural resolution of residues previously identified as important for IL-11 activity is presented. While IL-11 is thought to signal via a complex analogous to that of IL-6, comparisons show important differences between the two cytokines and it is suggested that IL-11 engages GP130 differently to IL-6. In addition to providing a structural platform for further study of IL-11, these data offer insight into the binding interactions of IL-11 with each of its receptors and the structural mechanisms underlying agonist and antagonist variants of the protein.
- Publisher
- IUCR
- Research Division(s)
- Inflammation
- Publisher's Version
- https://doi.org/10.1107/s1399004714012267
- Terms of Use/Rights Notice
- © International Union of Crystallography. Published by John Wiley & Sons Ltd
Creation Date: 2014-09-12 02:01:44