The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation
- Carotta, S; Willis, SN; Hasbold, J; Inouye, M; Pang, SH; Emslie, D; Light, A; Chopin, M; Shi, W; Wang, H; Morse, HC, 3rd; Tarlinton, DM; Corcoran, LM; Hodgkin, PD; Nutt, SL;
Publication Year 2014-10-06, Volume 211, Issue #11, Page 2169-81
- Journal Title
- J Exp Med
- Publication Type
- Journal Article
- Activated B cells undergo immunoglobulin class-switch recombination (CSR) and differentiate into antibody-secreting plasma cells. The distinct transcriptomes of B cells and plasma cells are maintained by the antagonistic influences of two groups of transcription factors: those that maintain the B cell program, including BCL6 and PAX5, and plasma cell-promoting factors, such as IRF4 and BLIMP-1. We show that the complex of IRF8 and PU.1 controls the propensity of B cells to undergo CSR and plasma cell differentiation by concurrently promoting the expression of BCL6 and PAX5 and repressing AID and BLIMP-1. As the PU.1-IRF8 complex functions in a reciprocal manner to IRF4, we propose that concentration-dependent competition between these factors controls B cell terminal differentiation.
- Rockefeller University Press
- WEHI Research Division(s)
- Molecular Immunology; Immunology
- Publisher's Version
- Rights Notice
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Creation Date: 2014-10-13 02:21:48Last Modified: 2015-05-25 11:35:03