The transcription factors IRF8 and PU.1 negatively regulate plasma cell differentiation
Details
Publication Year 2014-10-06, Volume 211, Issue #11, Page 2169-81
Journal Title
J Exp Med
Publication Type
Journal Article
Abstract
Activated B cells undergo immunoglobulin class-switch recombination (CSR) and differentiate into antibody-secreting plasma cells. The distinct transcriptomes of B cells and plasma cells are maintained by the antagonistic influences of two groups of transcription factors: those that maintain the B cell program, including BCL6 and PAX5, and plasma cell-promoting factors, such as IRF4 and BLIMP-1. We show that the complex of IRF8 and PU.1 controls the propensity of B cells to undergo CSR and plasma cell differentiation by concurrently promoting the expression of BCL6 and PAX5 and repressing AID and BLIMP-1. As the PU.1-IRF8 complex functions in a reciprocal manner to IRF4, we propose that concentration-dependent competition between these factors controls B cell terminal differentiation.
Publisher
Rockefeller University Press
WEHI Research Division(s)
Molecular Immunology; Immunology
NHMRC Grants
NHMRC/575500 NHMRC/1054925
Rights Notice
This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org.ezp.lib.unimelb.edu.au/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).


Creation Date: 2014-10-13 02:21:48
Last Modified: 2015-05-25 11:35:03
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