A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo
- Author(s)
- Potts, KS; Sargeant, TJ; Markham, JF; Shi, W; Biben, C; Josefsson, EC; Whitehead, LW; Rogers, KL; Liakhovitskaia, A; Smyth, GK; Kile, BT; Medvinsky, A; Alexander, WS; Hilton, DJ; Taoudi, S;
- Details
- Publication Year 2014-07-25,Volume 124,Issue #17,Page 2725-2729
- Journal Title
- Blood
- Publication Type
- Journal Article
- Abstract
- In this study we test the assumption that the hematopoietic progenitor/colony-forming cells of the embryonic yolk sac, which are endowed with megakaryocytic potential, differentiate into the first platelet-forming cells in vivo. We demonstrate that from embryonic day (E) 8.5 all megakaryocyte-colony forming cells belong to the conventional hematopoietic progenitor cell compartment. Although these cells are indeed capable of generating polyploid megakaryocytes, they are not the source of the first platelet-forming cells. We show that proplatelet formation first occurs in a unique and previously unrecognized lineage of diploid platelet-forming cells, which develop within the yolk sac in parallel to hematopoietic progenitor cells but can be specified in the E8.5 Runx1-null embryo despite the absence of the progenitor cell lineage.
- Publisher
- American Society of Hematology
- Research Division(s)
- Molecular Medicine; Immunology; Cancer And Haematology; Bioinformatics
- Publisher's Version
- https://doi.org/10.1182/blood-2014-02-559468
- Terms of Use/Rights Notice
- Copyright © 2014 American Society of Hematology
Creation Date: 2014-09-12 02:01:43
Last Modified: 2014-11-28 09:02:29