A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo
Publication Year 2014-07-25,Volume 124,Issue #17,Page 2725-2729
Journal Title
Publication Type
Journal Article
In this study we test the assumption that the hematopoietic progenitor/colony-forming cells of the embryonic yolk sac, which are endowed with megakaryocytic potential, differentiate into the first platelet-forming cells in vivo. We demonstrate that from embryonic day (E) 8.5 all megakaryocyte-colony forming cells belong to the conventional hematopoietic progenitor cell compartment. Although these cells are indeed capable of generating polyploid megakaryocytes, they are not the source of the first platelet-forming cells. We show that proplatelet formation first occurs in a unique and previously unrecognized lineage of diploid platelet-forming cells, which develop within the yolk sac in parallel to hematopoietic progenitor cells but can be specified in the E8.5 Runx1-null embryo despite the absence of the progenitor cell lineage.
American Society of Hematology
WEHI Research Division(s)
Molecular Medicine; Immunology; Cancer And Haematology; Bioinformatics
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Creation Date: 2014-09-12 02:01:43
Last Modified: 2014-11-28 09:02:29
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