Quantitative intratumoural microdistribution and kinetics of (131)I-huA33 antibody in patients with colorectal carcinoma.
- Author(s)
- Ciprotti, M; Chong, G; Gan, HK; Chan, A; Murone, C; MacGregor, D; Lee, FT; Johns, TG; Heath, JK; Ernst, M; Burgess, AW; Scott, AM;
- Journal Title
- EJNMMI research
- Publication Type
- Journal Article
- Abstract
- The ability of recombinant antibodies to adequately penetrate into tumours is a key factor in achieving therapeutic effect; however, the behaviour of antibodies at a cellular level in tumours is poorly understood. The purpose of this study was to investigate those factors that influence the macroscopic and microscopic intratumoural distribution of an IgG1-humanized antibody, huA33, in colorectal tumours.
- Publisher
- Springer
- Research Division(s)
- Cell Signalling And Cell Death; Development And Cancer; Structural Biology
- Publisher's Version
- https://doi.org/10.1186/s13550-014-0022-x
- Open Access at Publisher's Site
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- © 2014 Ciprotti et al.; licensee Springer This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creation Date: 2014-07-30 02:50:03