Lymphoid tissue and plasmacytoid dendritic cells and macrophages do not share a common macrophage-dendritic cell-restricted progenitor.
- Author(s)
- Sathe, P; Metcalf, D; Vremec, D; Naik, SH; Langdon, WY; Huntington, ND; Wu, L; Shortman, K;
- Details
- Publication Year 2014-07-17,Volume 41,Issue #1,Page 104-15
- Journal Title
- Immunity
- Publication Type
- Journal Article
- Abstract
- The relationship between dendritic cells (DCs) and macrophages is often debated. Here we ask whether steady-state, lymphoid-tissue-resident conventional DCs (cDCs), plasmacytoid DCs (pDCs), and macrophages share a common macrophage-DC-restricted precursor (MDP). Using new clonal culture assays combined with adoptive transfer, we found that MDP fractions isolated by previous strategies are dominated by precursors of macrophages and monocytes, include some multipotent precursors of other hematopoietic lineages, but contain few precursors of resident cDCs and pDCs and no detectable common precursors restricted to these DC types and macrophages. Overall we find no evidence for a common restricted MDP leading to both macrophages and FL-dependent, resident cDCs and pDCs.
- Publisher
- Cell Press
- Research Division(s)
- Cancer And Haematology; Molecular Immunology; Immunology; Molecular Medicine
- Publisher's Version
- https://doi.org/10.1016/j.immuni.2014.05.020
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2014-07-30 02:50:01