Deciphering the epigenetic code of T lymphocytes
Author(s)
Allan, RS; Nutt, SL;
Details
Publication Year 2014-09, Volume 261, Issue #1, Page 50-61
Journal Title
Immunol Rev
Publication Type
Journal Article
Abstract
The multiple lineages and differentiation states that constitute the T-cell compartment all derive from a common thymic precursor. These distinct transcriptional states are maintained both in time and after multiple rounds of cell division by the concerted actions of a small set of lineage-defining transcription factors that act in conjunction with a suite of chromatin-modifying enzymes to activate, repress, and fine-tune gene expression. These chromatin modifications collectively provide an epigenetic code that allows the stable and heritable maintenance of the T-cell phenotype. Recently, it has become apparent that the epigenetic code represents a therapeutic target for a variety of immune cell disorders, including lymphoma and acute and chronic inflammatory diseases. Here, we review the recent advances in epigenetic regulation of gene expression, particularly as it relates to the T-cell differentiation and function.
Publisher
Wiley
Keywords
histone modification; T cell; gene expression; epigenetic
WEHI Research Division(s)
Molecular Immunology
Publisher's Version
https://doi.org/10.1111/imr.12207
NHMRC Grants
NHMRC/1049307
Rights Notice
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd


Creation Date: 2014-09-12 02:01:38
Last Modified: 0001-01-01 12:00:00
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