Insights and controversies into the role of the key apicomplexan invasion ligand, Apical Membrane Antigen 1
Details
Publication Year 2014-08-23, Volume 44, Issue #12, Page 853-7
Journal Title
Int J Parasitol
Publication Type
Journal Article
Abstract
Apicomplexan parasites are obligate intracellular pathogens that cause a host of human and animal diseases. These parasites have developed a universal mechanism of invasion involving formation of a 'moving junction' that provides a stable anchoring point through which the parasite invades host cells. The composition of the moving junction, particularly the presence of the protein Apical Membrane Antigen 1 (AMA1), has recently been the subject of some controversy. In this commentary we review findings that led to the current model of the moving junction complex and dissect the major conflicts to determine whether a substantial reassessment of the role of AMA1 is justified.
Publisher
Elsevier
Keywords
AMA1; Apicomplexa; Invasion; Moving junction
WEHI Research Division(s)
Infection And Immunity
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Creation Date: 2014-09-12 02:01:40
Last Modified: 2014-12-10 04:03:08
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