The double burden: a new-age pandemic meets an ancient infection

Author(s): Bridson, TL; Govan, BL; Norton, RE; Schofield, L; Ketheesan, N;
Details: Publication Year 2014-08-25,Volume 108,Issue #11,Page 676-678
Journal Title: Trans R Soc Trop Med Hyg
Publication Type: Journal Article
Abstract: Tuberculosis is responsible for significant morbidity and mortality in the tropics. Active TB develops when host defences are impaired. Epidemiological evidence and studies addressing the double burden of communicable and non-communicable diseases demonstrate a clear association between diabetes and susceptibility to TB, treatment failure and complications. The immune mechanisms involved in host-pathogen interactions in co-morbid TB-diabetes are not well defined and require further investigation. This combined with the increase in diabetes predominately in low- and middle-income countries where TB is prevalent has major health implications.
Publisher: OUP
Keywords: Diabetes; Infectious diseases; Susceptibility; Tuberculosis; Type 2 diabetes
Research Division(s): Infection And Immunity
Publisher's Version: https://doi.org/10.1093/trstmh/tru135
Terms of Use/Rights Notice: © The Author 2014. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Creation Date: 2014-09-12 02:01:39