Can you rely on Treg cells on the rebound?
- Details
- Publication Year 2014,Volume 44,Issue #12,Page 3504-3507
- Journal Title
- European journal of immunology
- Publication Type
- Journal Article
- Abstract
- FoxP3+ regulatory T (Treg) cells comprise a highly dynamic population that restrains autoreactivity. Although complete or long-term depletion of Foxp3+ CD4+ Treg cells in adults has been shown to result in chronic inflammation and autoimmune disease, the impact of transient Treg-cell depletion on self-reactive responses is poorly defined. A new study published in this issue of the European Journal of Immunology [Eur. J. Immunol. 2014. 44: XXXX-XXXX] shows that, although transient depletion of Treg cells in mice is swiftly followed by recovery of Tregcell numbers, the "rebounded" population fails to maintain tolerance, culminating in severe autoimmune gastritis. This commentary explores new questions about the quantitative and qualitative aspects of Treg-cell function in immunological tolerance raised by this study and others. This article is protected by copyright. All rights reserved.
- Publisher
- Wiley
- Keywords
- Autoimmune gastritis; Foxp3; Immune homeostasis; Immunological tolerance; Regulatory T (Treg) cells
- Research Division(s)
- Molecular Genetics Of Cancer
- Publisher's Version
- https://doi.org/10.1002/eji.201445273
- NHMRC Grants
- NHMRC/1049724,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2014-11-24 12:53:26
Last Modified: 2015-03-18 01:40:58