Helping themselves: optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells
- Author(s)
- Olson, MR; Seah, SG; Cullen, J; Greyer, M; Edenborough, K; Doherty, PC; Bedoui, S; Lew, AM; Turner, SJ;
- Details
- Publication Year 2014-10-22,Volume 193,Issue #11,Page 5420-33
- Journal Title
- Journal of Immunology
- Publication Type
- Journal Article
- Abstract
- Although CD4+ T cell help (Th) is critical for inducing optimal B cell and CD8+ T cell responses, it remains unclear whether induction of CD4+ Th responses postinfection are also dependent on CD4+ T cell help. In this study, we show that activation of adoptively transferred Th cells during primary influenza A virus (IAV) infection enhances both the magnitude and functional breadth of endogenous primary IAV-specific CD4+ T cell responses. This enhancement was dependent on CD154-CD40-dependent dendritic cell licensing and resulted in a greater recall capacity of IAV-specific CD4+ and CD8+ T memory responses after heterologous IAV infection. These data suggest that engaging pre-existing CD4 responses at the time of priming may be a strategy for improving cellular immunity after vaccination.
- Publisher
- ASI
- Research Division(s)
- Immunology
- Publisher's Version
- https://doi.org/10.4049/jimmunol.1303359
- NHMRC Grants
- NHMRC/1037321, NHMRC/1043414,
- Terms of Use/Rights Notice
- Copyright © 2014 by The American Association of Immunologists, Inc.
Creation Date: 2014-10-27 01:11:12
Last Modified: 2014-11-28 08:20:43