Interleukin-21-producing CD4(+) T cells promote type 2 immunity to house dust mites
- Coquet, JM; Schuijs, MJ; Smyth, MJ; Deswarte, K; Beyaert, R; Braun, H; Boon, L; Karlsson Hedestam, GB; Nutt, SL; Hammad, H; Lambrecht, BN;
Publication Year 2015-08-18, Volume 43, Issue #2, Page 318-30
- Journal Title
- Publication Type
- Journal Article
- Asthma is a T helper 2 (Th2)-cell-mediated disease; however, recent findings implicate Th17 and innate lymphoid cells also in regulating airway inflammation. Herein, we have demonstrated profound interleukin-21 (IL-21) production after house dust mite (HDM)-driven asthma by using T cell receptor (TCR) transgenic mice reactive to Dermatophagoides pteronyssinus 1 and an IL-21GFP reporter mouse. IL-21-producing cells in the mediastinal lymph node (mLN) bore characteristics of T follicular helper (Tfh) cells, whereas IL-21(+) cells in the lung did not express CXCR5 (a chemokine receptor expressed by Tfh cells) and were distinct from effector Th2 or Th17 cells. Il21r(-/-) mice developed reduced type 2 responses and the IL-21 receptor (IL-21R) enhanced Th2 cell function in a cell-intrinsic manner. Finally, administration of recombinant IL-21 and IL-25 synergistically promoted airway eosinophilia primarily via effects on CD4(+) lymphocytes. This highlights an important Th2-cell-amplifying function of IL-21-producing CD4(+) T cells in allergic airway inflammation.
- Cell Press
- WEHI Research Division(s)
- Molecular Immunology
- PubMed ID
- Publisher's Version
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- Refer to copyright notice on published article.
Creation Date: 2015-09-01 03:55:18Last Modified: 2015-09-01 03:57:10