Comparing oncological outcomes of laparoscopic versus open surgery for colon cancer: Analysis of a large prospective clinical database

Sammour, T; Jones, IT; Gibbs, P; Chandra, R; Steel, MC; Shedda, SM; Croxford, M; Faragher, I; Hayes, IP; Hastie, IA

Author(s): Sammour, T; Jones, IT; Gibbs, P; Chandra, R; Steel, MC; Shedda, SM; Croxford, M; Faragher, I; Hayes, IP; Hastie, IA;
Details: Publication Year 2015-06,Volume 111,Issue #7,Page 891-8
Journal Title: J Surg Oncol
Publication Type: Journal Article
Abstract: BACKGROUND: Oncological outcomes of laparoscopic colon cancer surgery have been shown to be equivalent to those of open surgery, but only in the setting of randomized controlled trials on highly selected patients. The aim of this study is to investigate whether this finding is generalizable to real world practice. METHODS: Analysis of prospectively collected data from the BioGrid Australia database was undertaken. Overall and cancer specific survival rates were compared with cox regression analysis controlling for the confounders of age, sex, BMI, ASA score, hospital site, year surgery performed, procedure, tumor stage, and adjuvant chemotherapy. RESULTS: Between 2003 and 2009, 1,106 patients underwent elective colon cancer resection. There were differences between the laparoscopic and open cohorts in BMI, procedure, post-operative complication rate, and tumor stage. When baseline confounders were accounted for using cox regression analysis, there was no difference in 5 year overall survival (chi(2) test 1.302, P = 0.254), or cancer specific survival (chi(2) test 0.028, P = 0.866). CONCLUSION: This large prospective clinical study validates previous trial results, and confirms that there is no difference in oncological outcome between laparoscopic and open surgery for colon cancer.
Publisher: Wiley
Keywords: Aged; Australia; Colectomy/*mortality; Colonic Neoplasms/mortality/pathology/*surgery; Female; Follow-Up Studies; Humans; Laparoscopy/*mortality; Length of Stay; Male; Neoplasm Staging; Postoperative Complications/*mortality; Prognosis; Prospective Studies; Survival Rate
Research Division(s): Systems Biology And Personalised Medicine
PubMed ID: 25712421
Publisher's Version: https://doi.org/10.1002/jso.23893
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2015-09-02 03:35:46

Last Modified: 2015-09-03 03:47:03