c-Myb is required for plasma cell migration to bone marrow after immunization or infection
- Author(s)
- Good-Jacobson, KL; O'Donnell, K; Belz, GT; Nutt, SL; Tarlinton, DM;
- Details
- Publication Year 2015-06-29,Volume 212,Issue #7,Page 1001-9
- Journal Title
- J Exp Med
- Publication Type
- Journal Article
- Abstract
- Plasma cell migration is crucial to immunity, but little is known about the molecular regulators of their migratory programs. Here, we detail the critical role of the transcription factor c-Myb in determining plasma cell location. In the absence of c-Myb, no IgG(+) antigen-specific plasma cells were detected in the bone marrow after immunization or virus infection. This was correlated with a dramatic reduction of plasma cells in peripheral blood, mislocalization in spleen, and an inability of c-Myb-deficient plasma cells to migrate along a CXCL12 gradient. Therefore, c-Myb plays an essential, novel role in establishing the long-lived plasma cell population in the BM via responsiveness to chemokine migration cues.
- Publisher
- Rockefeller University Press
- Research Division(s)
- Immunology; Molecular Immunology
- PubMed ID
- 26077717
- Publisher's Version
- https://doi.org/10.1084/jem.20150191
- NHMRC Grants
- NHMRC/1054925, NHMRC/1057707,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2015-09-02 03:35:45
Last Modified: 2016-04-20 12:18:25