SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity

Kedzierski, L; Clemens, EB; Bird, NL; Kile, BT; Belz, GT; Nicola, NA; Kedzierska, K; Nicholson, SE

Author(s): Kedzierski, L; Clemens, EB; Bird, NL; Kile, BT; Belz, GT; Nicola, NA; Kedzierska, K; Nicholson, SE;
Details: Publication Year 2015-11,Volume 93,Issue #10,Page 909-913
Journal Title: Immunol Cell Biol
Publication Type: Journal Article
Abstract: Suppressor of cytokine signaling (SOCS) proteins are key regulators of innate and adaptive immunity. Mice lacking functional SOCS4 are hypersusceptible to primary infection with influenza A virus (IAV), displaying dysregulated pro-inflammatory cytokine and chemokine production in the lungs, delayed viral clearance and impaired trafficking of influenza-specific CD8+ T cells to the site of infection. Therefore, we postulated that SOCS4 is a critical regulator of anti-viral immunity. Unexpectedly, SOCS4 was not required for CD8+ T-cell memory generation, nor was it required to efficiently recall those cells in response to secondary IAV infection. Wild-type or SOCS4-deficient mice primed and re-challenged with serologically different influenza strains, did not show differences in susceptibility to IAV and cleared the virus from the lungs at the same rate. We have not observed differences in trafficking or numbers of IAV-specific cells, numbers of resident memory T cells or in cytokine profiles in lungs of infected animals. Our data show that despite an impaired primary immune response in Socs4R108X/R108X mice, SOCS4 is dispensable for an efficient recall response to influenza virus infection.Immunology and Cell Biology advance online publication, 16 June 2015; doi:10.1038/icb.2015.55.
Publisher: NPG
Research Division(s): Chemical Biology; Molecular Immunology; Cancer And Haematology; Inflammation
PubMed ID: 26077508
Publisher's Version: https://doi.org/10.1038/icb.2015.55
NHMRC Grants: NHMRC/1016647, NHMRC/1023559,
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2015-10-28 03:35:35

Last Modified: 2015-12-09 03:47:53