Mitochondria and apoptosis: emerging concepts
- Journal Title
- F1000Prime Rep
- Publication Type
- Journal Article
- Abstract
- As mitochondria are the powerhouses of the cell, their damage during the cell suicide process of apoptosis is essentially responsible for cellular demise in most cells. A key family of proteins, the B-cell lymphoma-2 (BCL-2) family, determines the integrity of mitochondria in the face of apoptotic insult. A comprehensive understanding of the molecular details of how apoptosis is initiated and how it culminates is essential if apoptosis is to fulfil its undoubted potential as a therapeutic target to treat diseases ranging from cancer to neurodegenerative conditions. Recent advances have provided significant insight into the control of this fundamental process while prompting a re-evaluation of what was considered dogma in the field. Emerging evidence also points to a potential overarching control network that governs not only apoptosis but other fundamental mitochondrial processes, including mitochondrial fission/fusion and quality control.
- Publisher
- Faculty of 1000
- Research Division(s)
- Cell Signalling And Cell Death
- PubMed ID
- 26097715
- Link To PubMed Central Version
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447032/
- Publisher's Version
- https://doi.org/10.12703/P7-42
- NHMRC Grants
- NHMRC/1059290,
- ARC Grants
- ARC/FT100100791,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2015-07-15 02:16:02
Last Modified: 2016-06-14 02:34:45